:orphan: 





.. _d1cmp_cl_iov_05_fit:



One Compartment Model with Absorption and Inter-occasion Variance f[CL_isv]=0.5
###############################################################################

[Generated automatically as a Fitting summary]

Model Description
*****************


:Name: d1cmp_cl_iov_05

:Title: One Compartment Model with Absorption and Inter-occasion Variance f[CL_isv]=0.5

:Author: PoPy for PK/PD

:Abstract: 

| Population one Compartment Model with Absorption and Inter-occasion Variance
| Here f[CL_isv] true value is 0.5

:Keywords: one compartment model; dep_one_cmp_cl; iov

:Input Script: :download:`d1cmp_cl_iov_05_fit.pyml <d1cmp_cl_iov_05_fit.pyml>`

:Diagram: 


.. thumbnail:: d1cmp_cl_iov_05_fit.pyml_output/compartment_diagram.svg
    :width: 200px


Comparison
**********



Compare Main f[X]
=================


===============  ================  ==============  ============  =============
Variable Name      Starting Value    Fitted Value    Abs Change    Prop Change
===============  ================  ==============  ============  =============
f[KA]                      0.5000          0.2686        0.2314         0.4628
f[CL]                      1.0000          2.0943        1.0943         1.0943
f[V]                      15.0000         18.1651        3.1651         0.2110
===============  ================  ==============  ============  =============

Compare Noise f[X]
==================


===============  ================  ==============  ============  =============
Variable Name      Starting Value    Fitted Value    Abs Change    Prop Change
===============  ================  ==============  ============  =============
f[PNOISE_STD]              0.2000          0.0889        0.1111         0.5553
f[ANOISE_STD]              0.2000          0.0486        0.1514         0.7570
===============  ================  ==============  ============  =============

Compare Variance f[X]
=====================


===============  ================  ==============  ============  =============
Variable Name      Starting Value    Fitted Value    Abs Change    Prop Change
===============  ================  ==============  ============  =============
f[CL_isv]                  0.0100          0.2835        0.2735        27.3455
f[CL_iov]                  0.0100          0.0105        0.0005         0.0518
===============  ================  ==============  ============  =============

Individual simulated (sim) plots
================================



.. thumbnail:: images/fit_sim_grph_outputs/indOBS_vs_TIME/000001.svg
    :width: 200px


.. thumbnail:: images/fit_sim_grph_outputs/indOBS_vs_TIME/000002.svg
    :width: 200px


.. thumbnail:: images/fit_sim_grph_outputs/indOBS_vs_TIME/000003.svg
    :width: 200px


Alternatively see :ref:`d1cmp_cl_iov_05_simulated_sim_plots`

Population simulated (sim) plots
================================


.. list-table:: 
    :width: 90%

    * - .. thumbnail:: images/fit_sim_grph_outputs/allOBS_vs_TIME/comb_spag.svg
            :width: 200px
      - allOBS_vs_TIME

Outputs
*******



Final objective value
=====================

.. code-block:: pyml

    -365.3290


which required 1.22 iterations and took 83.60 seconds

Fitted f[X] values (after fitting)
==================================


.. code-block:: pyml

    f[KA] = 0.2686
    f[CL] = 2.0943
    f[V] = 18.1651
    f[PNOISE_STD] = 0.0889
    f[ANOISE_STD] = 0.0486
    f[CL_isv] = 0.2835
    f[CL_iov] = 0.0105



Fitted parameter .csv files
===========================


:Fixed Effects: :download:`fx_params.csv (fit) <d1cmp_cl_iov_05_fit.pyml_output/solN/fx_params.csv>`

:Random Effects: :download:`rx_params.csv (fit) <d1cmp_cl_iov_05_fit.pyml_output/solN/rx_params.csv>`

:Model params: :download:`mx_params.csv (fit) <d1cmp_cl_iov_05_fit.pyml_output/solN/mx_params.csv>`

:State values: :download:`sx_params.csv (fit) <d1cmp_cl_iov_05_fit.pyml_output/solN/sx_params.csv>`

:Predictions: :download:`px_params.csv (fit) <d1cmp_cl_iov_05_fit.pyml_output/solN/px_params.csv>`

:Likelihoods: :download:`lx_params.csv (fit) <d1cmp_cl_iov_05_fit.pyml_output/solN/lx_params.csv>`



Inputs
******


:Input Data: :download:`cx_obs_params.csv <cx_obs_params.csv>`


Starting f[X] values (before fitting)
=====================================


.. code-block:: pyml

    f[KA] = 0.5000
    f[CL] = 1.0000
    f[V] = 15.0000
    f[PNOISE_STD] = 0.2000
    f[ANOISE_STD] = 0.2000
    f[CL_isv] = 0.0100
    f[CL_iov] = 0.0100

