:orphan: 





.. _circ_sin_gen:



Sine circadian model
####################

[Generated automatically as a Generation summary]

Model Description
*****************


:Name: circ_sin

:Title: Sine circadian model

:Author: PoPy for PK/PD

:Abstract: 

| A PD Model based on the amount of drug in the body.
| The PD model uses a sine function which simulates a circadian rhythm for the generation of a biomarker.
| The amount in the central compartment is determined by CL and V, PK patameters , which have been previosly estimated for each individual.
| The amount in the central compartment influences the rate of production of a biomarker.

:Keywords: PD; Pharmacodynamics; sine function; Circadian rhythm

:Input Script: :download:`circ_sin_gen.pyml <circ_sin_gen.pyml>`

:Diagram: 


.. thumbnail:: circ_sin_gen.pyml_output/compartment_diagram.svg
    :width: 200px


Outputs
*******



Population simulated (sim) plots
================================


.. list-table:: 
    :width: 90%

    * - .. thumbnail:: images/gen_sim_grph_outputs/indOBS_vs_TIME/000001.svg
            :width: 200px
      - indOBS_vs_TIME

Generated parameter .csv files
==============================


:Fixed Effects: :download:`fx_params.csv (gen) <circ_sin_gen.pyml_output/fx_params.csv>`

:Random Effects: :download:`rx_params.csv (gen) <circ_sin_gen.pyml_output/rx_params.csv>`

:Model params: :download:`mx_params.csv (gen) <circ_sin_gen.pyml_output/mx_params.csv>`

:State values: :download:`sx_params.csv (gen) <circ_sin_gen.pyml_output/sx_params.csv>`

:Predictions: :download:`px_params.csv (gen) <circ_sin_gen.pyml_output/px_params.csv>`


:Observations: :download:`synthetic_data.csv (gen) <synthetic_data.csv>`


Inputs
******



True f[X] values (for simulation)
=================================


.. code-block:: pyml

    f[AMP] = 2.0000
    f[INT] = 8.0000
    f[KOUT] = 0.0500
    f[ANOISE] = 3.0000

