# Sine circadian model

[Generated automatically as a Generation summary]

## Model Description

Name:

  circ_sin

Title:

  Sine circadian model

Author:

  PoPy for PK/PD

Abstract:

A PD Model based on the amount of drug in the body.
The PD model uses a sine function which simulates a circadian rhythm for the generation of a biomarker.
The amount in the central compartment is determined by CL and V, PK patameters , which have been previosly estimated for each individual.
The amount in the central compartment influences the rate of production of a biomarker.

Keywords:

  PD; Pharmacodynamics; sine function; Circadian rhythm

Input Script:

  `circ_sin_gen.pyml`

Diagram:

## Outputs

### Population simulated (sim) plots

| indOBS_vs_TIME

### Generated parameter .csv files

Fixed Effects:

  `fx_params.csv (gen)`

Random Effects:

  `rx_params.csv (gen)`

Model params:

  `mx_params.csv (gen)`

State values:

  `sx_params.csv (gen)`

Predictions:

  `px_params.csv (gen)`

Observations:

  `synthetic_data.csv (gen)`

## Inputs

### True f[X] values (for simulation)

    f[AMP] = 2.0000
    f[INT] = 8.0000
    f[KOUT] = 0.0500
    f[ANOISE] = 3.0000