# One Compartment Model with Absorption and no inter-occasion Variance f[CL_iov]=0

[Generated automatically as a Tutorial summary]

## Model Description

Name:

  d1cmp_cl_iov_naive

Title:

  One Compartment Model with Absorption and no inter-occasion Variance f[CL_iov]=0

Author:

  PoPy for PK/PD

Abstract:

Population one Compartment Model with Absorption and Inter-occasion Variance
Here f[CL_iov] is not estimated it is set to zero.

Keywords:

  one compartment model; dep_one_cmp_cl; iov

Input Script:

  `d1cmp_cl_iov_naive.pyml`

Diagram:

## Comparison

### True objective value

    242.7372

### Final fitted objective value

    -203.5525

### Compare Main f[X]

Name | Initial | Fitted | True | Abs. Error | Prop. Error
--- | --- | --- | --- | --- | ---
f[KA] | 0.5 | 0.291 | 0.3 | 8.69e-03 | 2.90%
f[CL] | 1 | 2.48 | 3 | 5.22e-01 | 17.40%
f[V] | 15 | 22.5 | 20 | 2.51e+00 | 12.56%

### Compare Noise f[X]

Name | Initial | Fitted | True | Abs. Error | Prop. Error
--- | --- | --- | --- | --- | ---
f[PNOISE_STD] | 0.2 | 0.413 | 0.1 | 3.13e-01 | 312.50%
f[ANOISE_STD] | 0.2 | 0.0709 | 0.05 | 2.09e-02 | 41.76%

### Compare Variance f[X]

Name | Initial | Fitted | True | Abs. Error | Prop. Error
--- | --- | --- | --- | --- | ---
f[CL_isv] | 0.01 | 0.141 | 0.2 | 5.86e-02 | 29.32%

## Outputs

### Fitted f[X] values (after fitting)

    f[KA] = 0.2913
    f[CL] = 2.4780
    f[V] = 22.5113
    f[PNOISE_STD] = 0.4125
    f[ANOISE_STD] = 0.0709
    f[CL_isv] = 0.1414
    f[CL_iov] = 0.0000

### Generated data .csv file

Synthetic Data:

  `synthetic_data.csv`

### Gen and Fit Summaries

- Gen: One Compartment Model with Absorption and no inter-occasion Variance f[CL_iov]=0 (gen)

- Fit: One Compartment Model with Absorption and no inter-occasion Variance f[CL_iov]=0 (fit)

## Inputs

### True f[X] values (for simulation)

    f[KA] = 0.3000
    f[CL] = 3.0000
    f[V] = 20.0000
    f[PNOISE_STD] = 0.1000
    f[ANOISE_STD] = 0.0500
    f[CL_isv] = 0.2000
    f[CL_iov] = 0.1000

### Starting f[X] values (before fitting)

    f[KA] = 0.5000
    f[CL] = 1.0000
    f[V] = 15.0000
    f[PNOISE_STD] = 0.2000
    f[ANOISE_STD] = 0.2000
    f[CL_isv] = 0.0100
    f[CL_iov] = 0.0000