# One Compartment Model with Absorption and Inter-subject Variance f[CL_isv]=0.2

[Generated automatically as a Tutorial summary]

## Model Description

Name:

  d1cmp_cl_isv

Title:

  One Compartment Model with Absorption and Inter-subject Variance f[CL_isv]=0.2

Author:

  PoPy for PK/PD

Abstract:

Population one Compartment Model with Absorption and Inter-subject Variance

Keywords:

  one compartment model; dep_one_cmp_cl

Input Script:

  `d1cmp_cl_isv.pyml`

Diagram:

## Comparison

### True objective value

    -362.6880

### Final fitted objective value

    -371.3278

### Compare Main f[X]

Name | Initial | Fitted | True | Abs. Error | Prop. Error
--- | --- | --- | --- | --- | ---
f[KA] | 0.5 | 0.264 | 0.3 | 3.58e-02 | 11.92%
f[CL] | 1 | 2.74 | 3 | 2.58e-01 | 8.61%
f[V] | 15 | 19.2 | 20 | 8.02e-01 | 4.01%

### Compare Noise f[X]

Name | Initial | Fitted | True | Abs. Error | Prop. Error
--- | --- | --- | --- | --- | ---
f[PNOISE_STD] | 0.2 | 0.113 | 0.1 | 1.31e-02 | 13.10%
f[ANOISE_STD] | 0.2 | 0.0417 | 0.05 | 8.32e-03 | 16.64%

### Compare Variance f[X]

Name | Initial | Fitted | True | Abs. Error | Prop. Error
--- | --- | --- | --- | --- | ---
f[CL_isv] | 0.01 | 0.165 | 0.2 | 3.53e-02 | 17.65%

## Outputs

### Fitted f[X] values (after fitting)

    f[KA] = 0.2642
    f[CL] = 2.7416
    f[V] = 19.1975
    f[PNOISE_STD] = 0.1131
    f[ANOISE_STD] = 0.0417
    f[CL_isv] = 0.1647

### Generated data .csv file

Synthetic Data:

  `synthetic_data.csv`

### Gen and Fit Summaries

- Gen: One Compartment Model with Absorption and Inter-subject Variance f[CL_isv]=0.2 (gen)

- Fit: One Compartment Model with Absorption and Inter-subject Variance f[CL_isv]=0.2 (fit)

## Inputs

### True f[X] values (for simulation)

    f[KA] = 0.3000
    f[CL] = 3.0000
    f[V] = 20.0000
    f[PNOISE_STD] = 0.1000
    f[ANOISE_STD] = 0.0500
    f[CL_isv] = 0.2000

### Starting f[X] values (before fitting)

    f[KA] = 0.5000
    f[CL] = 1.0000
    f[V] = 15.0000
    f[PNOISE_STD] = 0.2000
    f[ANOISE_STD] = 0.2000
    f[CL_isv] = 0.0100